Hmm! That much intelligence and organization to produce a tiny modification in life?

The existence of complex specified information

The existence of a true code that guides protein assembly.

The information coded into DNA does not depend on the chemistry and physics of the bond environment

"While some may suggest the creation of artificial life makes the need for a Creator obsolete, in reality it does the opposite. As both the top-down and bottom-up approaches demonstrate, only by deliberate effort, inordinate ingenuity, and astonishing skill can synthetic biologists even begin the process of making artificial life. This work reinforces God's status as Creator, whether skeptics like it or not, because it empirically demonstrates that even the simplest life-form cannot arise without the involvement of an intelligent, intentional agent. When Christians support work in synthetic biology, they are encouraging scientific advance that adds to the weight of evidence for God's existence." Rana, "Creating Life in the Lab", p197.

What parts of the synthetic processes seem beyond "chance and necessity"?

Assertions about tasks that require intelligence:

Chance and necessity can't build a formal code.

Chance and necessity can't handle a chicken-and-egg problem.